Single low-dose primaquine to reduce malaria transmission
نویسندگان
چکیده
منابع مشابه
Modelling the therapeutic dose range of single low dose primaquine to reduce malaria transmission through age-based dosing
BACKGROUND Low-dose primaquine is a key candidate for use in malaria transmission reduction and elimination campaigns such as mass drug administration (MDA). Uncertainty about the therapeutic dose range (TDR) required for general and paediatric populations challenge the implementation of the World Health Organisation's recommendation to add 0.25 mg/kg to current standard antimalarial treatment ...
متن کاملErratum to: An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia
Erratum After publication of the original article [1], it came to the authors’ attention that there was an error in the PQ pharmacokinetics sub-section of the Background section. The following sentence is affected: “There is no PK interaction between PQ and either artesunate-pyronaridine [76] or mefloquine [69, 77]; no PK interaction data exist for PQ and artemetherlumefantrine (AL).” This sent...
متن کاملAn optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia
BACKGROUND In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to block the transmission of Plasmodium falciparum without testing for glucose-6-phosphate dehydrogenase deficiency. The targeted group was non-pregnant patients aged ≥ 1 year (later changed to ≥ 6 months) with acute u...
متن کاملEthics, Economics, and the Use of Primaquine to Reduce Falciparum Malaria Transmission in Asymptomatic Populations
Yoel Lubell and colleagues consider ethical and economic perspectives on mass drug administration of primaquine to limit transmission of P. falciparum malaria. Please see later in the article for the Editors' Summary.
متن کاملSingle dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission in Cambodia: An open-label randomized trial
BACKGROUND Single low dose primaquine (SLD PQ, 0.25mg/kg) is recommended in combination with artemisinin-based combination therapy (ACT) as a gametocytocide to prevent Plasmodium falciparum transmission in areas threatened by artemisinin resistance. To date, no randomized controlled trials have measured primaquine's effect on infectiousness to Anopheline mosquitoes in Southeast Asia. METHODS ...
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ژورنال
عنوان ژورنال: The Lancet Infectious Diseases
سال: 2014
ISSN: 1473-3099
DOI: 10.1016/s1473-3099(13)70288-3